|
rs1990760
|
|
|
0.730 |
GeneticVariation |
BEFREE |
This study showed an association of rs1990760 polymorphism in the IFIH1 gene in the development of GD, LADA diabetes and MS within the Polish population.
|
31733941 |
2020 |
|
rs3130253
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Three SNPs linked to MS pathology-associated genes showed a significant association with either proportion of active lesions (rs3130253/MOG), incidence of cortical gray matter lesions (rs1064395/NCAN) or the proportion of remyelinated lesions (rs5742909/CTLA4).
|
31228212 |
2020 |
|
rs56149945
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Meanwhile, the long non-coding RNA (lncRNA) <i>growth arrest specific 5</i> (<i>GAS5</i>) interacts with GR through binding to the DNA-binding domain (DBD) region and reduces GR transcriptional activity.<b>Methods:</b> The purpose of our study was to evaluate the association between MS and polymorphisms within <i>NR3C1</i> (rs6189/6190, rs56149945, rs41423247) and <i>GAS5</i> (rs55829688) genes in 300 relapsing-remitting MS patients and 300 healthy subjects.<b>Results:</b> We demonstrated significant differences in distribution of genotype, allele and haplotype frequencies of rs6189, rs41423247 and rs55829688 between the study groups.<b>Conclusion:</b> Our data may suggest that rs6189, rs41423247 and rs55829688 are associated with the increased risk of MS development.
|
31724909 |
2020 |
|
rs11639084
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To investigate the role of RORA gene as a biomarker of patient's responsiveness, the present study have analyzed the frequency of two polymorphisms (rs4774388 and rs11639084) within this gene between responder (n = 105) and nonresponder (n = 65) groups of MS patients in comparison with 200 healthy controls.
|
31649263 |
2020 |
|
rs4774388
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To investigate the role of RORA gene as a biomarker of patient's responsiveness, the present study have analyzed the frequency of two polymorphisms (rs4774388 and rs11639084) within this gene between responder (n = 105) and nonresponder (n = 65) groups of MS patients in comparison with 200 healthy controls.
|
31649263 |
2020 |
|
rs1064395
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNPs linked to MS pathology-associated genes showed a significant association with either proportion of active lesions (rs3130253/MOG), incidence of cortical gray matter lesions (rs1064395/NCAN) or the proportion of remyelinated lesions (rs5742909/CTLA4).
|
31228212 |
2020 |
|
rs11957313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNPs linked to MS clinical severity showed a significant association between the genotype and either the proportion of active lesions (rs2234978/FAS and rs11957313/KCNIP1) or the proportion of mixed active/inactive lesions (rs8056098/CLEC16A).
|
31228212 |
2020 |
|
rs2234978
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNPs linked to M</span>S clinical severity showed a significant association between the genotype and either the proportion of active lesions (rs2234978/FAS and rs11957313/KCNIP1) or the proportion of mixed active/inactive lesions (rs8056098/CLEC16A).
|
31228212 |
2020 |
|
rs2501432
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant genetic association was observed between Q63R polymorphism and MS.
|
31407233 |
2020 |
|
rs35761398
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant genetic association was observed between Q63R polymorphism and MS.
|
31407233 |
2020 |
|
rs41423247
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meanwhile, the long non-coding RNA (lncRNA) <i>growth arrest specific 5</i> (<i>GAS5</i>) interacts with GR through binding to the DNA-binding domain (DBD) region and reduces GR transcriptional activity.<b>Methods:</b> The purpose of our study was to evaluate the association between MS and polymorphisms within <i>NR3C1</i> (rs6189/6190, rs56149945, rs41423247) and <i>GAS5</i> (rs55829688) genes in 300 relapsing-remitting MS patients and 300 healthy subjects.<b>Results:</b> We demonstrated significant differences in distribution of genotype, allele and haplotype frequencies of rs6189, rs41423247 and rs55829688 between the study groups.<b>Conclusion:</b> Our data may suggest that rs6189, rs41423247 and rs55829688 are associated with the increased risk of MS development.
|
31724909 |
2020 |
|
rs55829688
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meanwhile, the long non-coding RNA (lncRNA) <i>growth arrest specific 5</i> (<i>GAS5</i>) interacts with GR through binding to the DNA-binding domain (DBD) region and reduces GR transcriptional activity.<b>Methods:</b> The purpose of our study was to evaluate the association between MS and polymorphisms within <i>NR3C1</i> (rs6189/6190, rs56149945, rs41423247) and <i>GAS5</i> (rs55829688) genes in 300 relapsing-remitting MS patients and 300 healthy subjects.<b>Results:</b> We demonstrated significant differences in distribution of genotype, allele and haplotype frequencies of rs6189, rs41423247 and rs55829688 between the study groups.<b>Conclusion:</b> Our data may suggest that rs6189, rs41423247 and rs55829688 are associated with the increased risk of MS development.
|
31724909 |
2020 |
|
rs5742909
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNPs linked to MS pathology-associated genes showed a significant association with either proportion of active lesions (rs3130253/MOG), incidence of cortical gray matter lesions (rs1064395/NCAN) or the proportion of remyelinated lesions (rs5742909/CTLA4).
|
31228212 |
2020 |
|
rs6189
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meanwhile, the long non-coding RNA (lncRNA) <i>growth arrest specific 5</i> (<i>GAS5</i>) interacts with GR through binding to the DNA-binding domain (DBD) region and reduces GR transcriptional activity.<b>Methods:</b> The purpose of our study was to evaluate the association between MS and polymorphisms within <i>NR3C1</i> (rs6189/6190, rs56149945, rs41423247) and <i>GAS5</i> (rs55829688) genes in 300 relapsing-remitting MS patients and 300 healthy subjects.<b>Results:</b> We demonstrated significant differences in distribution of genotype, allele and haplotype frequencies of rs6189, rs41423247 and rs55829688 between the study groups.<b>Conclusion:</b> Our data may suggest that rs6189, rs41423247 and rs55829688 are associated with the increased risk of MS development.
|
31724909 |
2020 |
|
rs8056098
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNPs linked to MS clinical severity showed a significant association between the genotype and either the proportion of active lesions (rs2234978/FAS and rs11957313/KCNIP1) or the proportion of mixed active/inactive lesions (rs8056098/CLEC16A).
|
31228212 |
2020 |
|
rs879761216
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant genetic association was observed between Q63R polymorphism and MS.
|
31407233 |
2020 |
|
rs2104286
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We observed that MS-associated <i>IL2RA</i> SNPs rs2104286 and rs11256593 are associated with expression of CD25 in CD4<sup>+</sup> but not CD8<sup>+</sup> T cells.
|
31242590 |
2019 |
|
rs1800693
|
|
|
0.880 |
GeneticVariation |
BEFREE |
Genetic polymorphism (rs1800693) of TNFRSF1A (type 1 tumour necrosis factor receptor) encodes a potentially anti-inflammatory soluble truncated form of the p55 receptor, which is associated with predisposition to multiple sclerosis but protection against ankylosing spondylitis (AS).
|
29535371 |
2019 |
|
rs703842
|
|
|
0.840 |
GeneticVariation |
BEFREE |
No association of rs703842 with MS disability progression or calcidiol serum level was found.
|
30875612 |
2019 |
|
rs17066096
|
|
|
0.810 |
GeneticVariation |
BEFREE |
We show that monocytes from carriers of the risk genotype of rs17066096 express more IL-22BP in vitro and cerebrospinal fluid levels of IL-22BP correlate with MS lesion load on magnetic resonance imaging.
|
31292217 |
2019 |
|
rs6062314
|
|
|
0.810 |
GeneticVariation |
GWASCAT |
Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.
|
31407831 |
2019 |
|
rs9271640
|
|
|
0.810 |
GeneticVariation |
BEFREE |
There are eQTLs in linkage with lead MS variants in 25 genes including the multitissue eQTL, rs9271640, for <i>HLA-DRB1</i>/<i>DRB5</i>.
|
31482761 |
2019 |
|
rs1250550
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.
|
31407831 |
2019 |
|
rs1323292
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.
|
31407831 |
2019 |
|
rs140522
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.
|
31407831 |
2019 |